Search results for "Biliary tract"

showing 10 items of 85 documents

Targeting Angiogenesis in Biliary Tract Cancers: An Open Option

2017

Abstract: Biliary tract cancers (BTCs) are characterized by a bad prognosis and the armamentarium of drugs for their treatment is very poor. Although the inflammatory status of biliary tract represents the first step in the cancerogenesis, the microenvironment also plays a key role in the pathogenesis of BTCs, promoting tumor angiogenesis, invasion and metastasis. Several molecules, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), are involved in the angiogenesis process and their expression on tumor samples has been explored as prognostic marker in both cholangiocarcinoma and gallbladder cancer. Recent studies evaluated the genomic landscape of BTCs and…

0301 basic medicineMAPK/ERK pathwayVascular Endothelial Growth Factor AAngiogenesisDrug Evaluation PreclinicalTyrosine kinase inhibitorAngiogenesis InhibitorsReviewFibroblast growth factorCatalysiMetastasisAntineoplastic Agentlcsh:Chemistrychemistry.chemical_compoundangiogenesis0302 clinical medicinetyrosine kinase inhibitorsMolecular Targeted Therapylcsh:QH301-705.5SpectroscopyClinical Trials as TopicMonoclonal antibodieNeovascularization Pathologicvascular endothelial growth factorComputer Science Applications1707 Computer Vision and Pattern RecognitionGeneral MedicineComputer Science ApplicationsVascular endothelial growth factorGene Expression Regulation NeoplasticAngiogenesiChemistryBiliary Tract NeoplasmsTreatment OutcomeBiliary Tract Neoplasm030220 oncology & carcinogenesismonoclonal antibodiesTyrosine kinaseAngiogenesis InhibitorHumanSignal TransductionProtein Kinase InhibitorAntineoplastic Agentsbiliary tract cancersBiologyModels BiologicalAngiogenesis; Biliary tract cancers; Monoclonal antibodies; Tyrosine kinase inhibitors; Vascular endothelial growth factor; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Biliary Tract Neoplasms; Clinical Trials as Topic; Drug Evaluation Preclinical; Gene Expression Regulation Neoplastic; Genetic Variation; Humans; Models Biological; Neovascularization Pathologic; Protein Kinase Inhibitors; Signal Transduction; Treatment Outcome; Vascular Endothelial Growth Factor A; Molecular Targeted Therapy; Catalysis; Molecular Biology; Spectroscopy; Computer Science Applications1707 Computer Vision and Pattern Recognition; Physical and Theoretical Chemistry; Organic Chemistry; Inorganic ChemistryCatalysisInorganic Chemistry03 medical and health sciencesIn vivomedicineAnimalsHumansPhysical and Theoretical ChemistryGallbladder cancerMolecular BiologyProtein Kinase InhibitorsBiologyAnimalOrganic ChemistryGenetic Variationmedicine.disease030104 developmental biologychemistrylcsh:Biology (General)lcsh:QD1-999Immunologyangiogenesis; biliary tract cancers; monoclonal antibodies; tyrosine kinase inhibitors; vascular endothelial growth factorCancer researchBiliary tract cancerInternational Journal of Molecular Sciences
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Bactibilia in women affected with diseases of the biliary tract and pancreas. A STROBE guidelines-adherent cross-sectional study in Southern Italy.

2018

Abstract Purpose. Bile is a hepatobiliary lipid-rich sterile solution, and its colonization by microorganisms defines the condition of bactibilia. In this study, we aimed to assess the bile microbiological flora and its potential link with comorbidity in women. Methodology. We performed a microbiologic investigation on 53 female patients with biliopancreatic diseases who granted consent, and we analysed the data using a MATLAB platform. Results. We found that the most frequent disease associated with bactibilia was pancreas head carcinoma (PHC) (P=0.0015), while the least frequent disease was gall bladder carcinoma (GBC) (P=0.0002). The most common microorganisms were Pseudomonas spp. (P&lt…

0301 basic medicineMicrobiology (medical)medicine.medical_specialtyPancreatic diseaseMediterranean dietCross-sectional studyMicrobiologyGastroenterologyBiliary disease03 medical and health sciences0302 clinical medicineInternal medicineGram-Negative BacteriamedicineCarcinomaBileHumansBiliary TractAgedAged 80 and overbusiness.industryMortality rateGeneral MedicineMiddle Agedmedicine.diseaseComorbidityBactibiliaPancreatic Neoplasms030104 developmental biologyBiliary Tract NeoplasmsCross-Sectional StudiesItalyBiliary tract030220 oncology & carcinogenesisFemalebusinessJournal of medical microbiology
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AB052. P-20. Phase 2, open-label study of second-line M7824 treatment in patients with locally advanced or metastatic biliary tract cancer

2019

BACKGROUND: Transforming growth factor β (TGF-β) signaling promotes tumor immunosuppression; its inhibition in the tumor microenvironment may enhance the response to anti-PD-L1 treatment. M7824 is an innovative first-in-class bifunctional fusion protein composed of 2 extracellular domains of TGF-βRII (a TGF-β “trap”) fused to a human IgG1 mAb against PD-L1. Building upon encouraging efficacy observed in a phase 1 study, the present study will evaluate M7824 clinical benefit in patients with pretreated biliary tract cancer (BTC). METHODS: This multicenter, international trial is evaluating M7824 monotherapy in patients with locally advanced or metastatic (LA/M) BTC unselected for tumor PD-L1…

0301 basic medicineTumor microenvironmentBiliary tract cancerbiologybusiness.industrymedicine.drug_classMonoclonal antibodyFusion protein03 medical and health sciences030104 developmental biology0302 clinical medicine030220 oncology & carcinogenesisPD-L1Poster AbstractsCancer researchExtracellularbiology.proteinMedicineIn patientbusinessTransforming growth factor
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<p>The microbiota of the bilio-pancreatic system: a cohort, STROBE-compliant study</p>

2019

Background: The gut microbiota play an essential role in protecting the host against pathogenic microorganisms by modulating immunity and regulating metabolic processes. In response to environmental factors, microbes can hugely alter their metabolism. These factors can substantially impact the host and have potential pathologic implications. Particularly pathogenic microorganisms colonizing pancreas and biliary tract tissues may be involved in chronic inflammation and cancer evolution. Purpose: To evaluate the effect of bile microbiota on survival in patients with pancreas and biliary tract disease (PBD). Patients and Methods: We investigated 152 Italian patients with cholelithiasis (CHL), …

0301 basic medicinemedicine.medical_specialty030106 microbiologyGut floraGastroenterology03 medical and health sciences0302 clinical medicineImmunityInternal medicineCarcinomaMedicinePharmacology (medical)030212 general & internal medicinePharmacologybiologybusiness.industryGallbladderCancermedicine.diseasebiology.organism_classificationInfectious Diseasesmedicine.anatomical_structureBiliary tractPancreatitisbusinessPancreasInfection and Drug Resistance
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Ischemic-type biliary lesions after liver transplantation: a retrospective analysis of risk factors and outcome.

2013

BACKGROUND Ischemic-type biliary lesions (ITBL) are the most troublesome complications after liver transplantation. Their cause remains unknown and, although some risk factors have been identified, results from different research groups are often conflicting. The goal of this study was to investigate potential risk factors for ITBL. METHODS 565 transplantations performed between September 1997 and August 2010 were identified and divided into two cohorts: 77 in which the patient developed ITBL and 488 in which no ITBL occurred. The following factors were analyzed: donor age, patient Child-Pugh score, cold ischemia time, total ischemia time, type of perfusion solution, shipped versus non-ship…

AdultMalemedicine.medical_specialtyAdolescentBiliary Tract Diseasesmedicine.medical_treatmentLiver transplantationLogistic regressionCold Ischemia TimeGastroenterologyGeneral Biochemistry Genetics and Molecular BiologyYoung AdultText miningRisk FactorsInternal medicinemedicineHumansAlleleAgedRetrospective StudiesProportional hazards modelbusiness.industryTransplant Waiting ListMiddle AgedLiver TransplantationFemalebusinessPerfusion
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A prospective evaluation of magnetic resonance cholangiopancreatography in patients with suspected bile duct obstruction.

1998

Background—The value of magnetic resonance cholangiopancreatography (MRCP) is under debate.Aims—To assess the diagnostic accuracy of MRCP and endoscopic retrograde cholangiopancreatography (ERCP) and to determine whether MRCP may help to prevent unnecessary interventional procedures.Methods—Eighty six patients with suspected common bile duct obstruction who presented between January and December 1996 were enrolled. Twenty six were excluded due to anatomical reasons or because MRCP or ERCP could not be performed successfully. Results of MRCP were interpreted by two radiologists and a gastroenterologist unaware of clinical diagnosis. Final diagnosis was determined by ERCP and histopathologica…

AdultMalemedicine.medical_specialtyAdolescentSensitivity and SpecificityCholestasismedicineHumansProspective StudiesChildLetters to the EditorAgedPancreatic ductCholangiopancreatography Endoscopic RetrogradeMagnetic resonance cholangiopancreatographyEndoscopic retrograde cholangiopancreatographyCholestasisCommon bile ductmedicine.diagnostic_testPancreas and Biliary TractBile ductbusiness.industryGastroenterologyMagnetic resonance imagingMiddle Agedmedicine.diseaseMagnetic Resonance Imagingmedicine.anatomical_structureBiliary tractFemaleRadiologybusinessGut
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Electromagnetically Generated Extracorporeal Shock Wave Lithotripsy and Adjuvant Combined Oral Litholysis for Therapy of Symptomatic Gallbladder Ston…

1991

A prospective study was conducted to evaluate effectivity, problems and adverse effects of extracorporeal shock wave lithotripsy (ESWL) using a newly developed electromagnetic biliary lithotriptor (Lithostar Plus, Siemens, Erlangen, FRG) for the treatment of selected patients presenting with symptomatic cholecystolithiasis. In addition to generally accepted criteria for the selection of patients, gallbladder contractility was established and pigment stones were excluded by computed tomography (CT). 80 out of 486 patients (63 females, 17 males, mean age 36, range 17-76 years) were selected for ESWL using a standardized diagnostic program. 62 out of 80 patients participating in the study had …

AdultMalemedicine.medical_specialtyAdolescentmedicine.medical_treatmentAdministration OralGallbladder StoneLithotripsyChenodeoxycholic AcidCholelithiasisLithotripsymedicineHumansProspective StudiesAgedUltrasonographybusiness.industryGallbladderUrsodeoxycholic AcidGastroenterologyMiddle AgedCombined Modality TherapyExtracorporeal shock wave lithotripsySurgerymedicine.anatomical_structureFemaleRadiologybusinessAdjuvantBiliary tract diseaseDigestion
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Intrahepatic biliary anatomy derived from right graft adult live donor liver transplantation

2008

Abstract Objective The successful management of the bile duct in right graft adult live donor liver transplantation requires knowledge of both its central (hilar) and distal (sectorial) anatomy. The purpose of this study was to provide a systematic classification of its branching patterns to enhance clinical decision-making. Patients and Methods We analyzed three-dimensional computed tomography (3-D CT) imaging reconstructions of 139 potential live liver donors evaluated at our institution between January 2003 and June 2007. Results Fifty-four (n = 54 or 38.8%) donor candidates had a normal (classic) hilar and sectorial right bile duct anatomy (type I). Seventy-eight (n = 78 or 56.1%) cases…

AdultMalemedicine.medical_specialtyLive donormedicine.medical_treatmentCholecystographyHepatic Duct CommonLiver transplantationliverImage Processing Computer-AssistedLiving DonorsmedicineHumansRetrospective StudiesTransplantationmedicine.diagnostic_testBile ductbusiness.industryGallbladderGallbladderRetrospective cohort studyMiddle AgedCholecystographyLiver TransplantationSurgeryBiliary anatomymedicine.anatomical_structureBiliary tractFemaleSurgeryTomography X-Ray Computedbusiness
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Is ERCP manometry useful in the choice of treatment of stones of the common bile duct?

1988

To verify the appropriateness of sphincterotomy as the treatment of choice of choledocholithiasis, since 1980 we have been using endoscopic retrograde cholangiopancreatographic (ERCP) manometry of the sphincter of Oddi (SO). This method allows direct investigation of SO motor activity and provides useful information regarding the presence of benign papillary stenosis (BPS). Thirty-four patients were investigated because the radiological examination indicated BPS might be present. Of these, 20 had common bile duct (CBD) stones, while the remaining 14 presented with biliarylike pain and one or more of the following: CBD dilation (larger than 12 mm); emptying of the ERCP contrast medium took l…

AdultMalemedicine.medical_specialtyManometryConstriction PathologicGallstonesInternal medicineSphincter of OddiPressureMedicineHumansSphincter of OddiAgedCholangiopancreatography Endoscopic RetrogradeCommon bile ductmedicine.diagnostic_testbusiness.industryHepatologyMiddle Agedmedicine.diseaseEndoscopySurgerymedicine.anatomical_structureBiliary tractAbnormal Liver Function TestSurgeryFemalePeristalsisPapillary stenosisbusinessAbdominal surgerySurgical endoscopy
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Long-term results (7 to 10 years) of endoscopic papillotomy for choledocholithiasis. Multivariate analysis of prognostic factors for the recurrence o…

1998

Abstract Background: The long-term outcome after endoscopic papillotomy is poorly defined. The aim of this study was to determine the long-term results of this method in the treatment of common duct calculi and to determine which prognostic factors are associated with the relapse of biliary symptoms. Methods: Between 1985 and 1988, 223 consecutive (149 women, mean age 67.9 years) patients underwent endoscopic papillotomy for duct stones; 127 had already undergone cholecystectomy or underwent this operation during the same hospitalization. Follow-up data were obtained retrospectively from the patients and patients' relatives and general practitioners. Results: The procedure was successful in…

AdultMalemedicine.medical_specialtyMultivariate analysismedicine.medical_treatmentGallstonesGastroenterologyDisease-Free SurvivalSphincterotomy EndoscopicPostoperative ComplicationsRecurrenceInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingAgedRetrospective StudiesAged 80 and overmedicine.diagnostic_testBile ductbusiness.industryGallbladderGastroenterologyRetrospective cohort studyMiddle AgedPrognosisSurgeryEndoscopymedicine.anatomical_structureTreatment OutcomeBiliary tractMultivariate AnalysisCholecystectomyFemalebusinessDuct (anatomy)Follow-Up StudiesGastrointestinal endoscopy
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